Effectiveness of Ascophyllum nodosum and Fucus vesiculosus on Metabolic Syndrome Components: A Real-World, Observational Study

Table 2

Estimated marginal means (95% CI) of the parameters of interest at baseline and their change after 90 days and 180 days of treatment.

Parameter	Baseline value	Change at 90 days	value (90 days vs. baseline)	Change at 180 days	value (180 days vs. baseline)
Weight (kg)	91.3 [89.5; 93.0]	-4.6 [-5.0; -4.2]	<0.0001	-7.3 [-8.0; -6.6]	<0.0001
Waist circumference (cm)	107.9 [105.9; 109.9]	-4.3 [-4.8; -3.8]	<0.0001	-7.5 [-8.2; -6.8]	<0.0001
Fasting blood glucose (mg/dL)	122.6 [120.1; 125.0]	-10.6 [-11.8; -9.3]	<0.0001	-16.3 [-17.8; -14.7]	<0.0001
HbA1c (%)	6.66 [6.55; 6.77]	-0.33 [-0.39; -0.27]	<0.0001	-0.55 [-0.62; -0.49]	<0.0001
Systolic blood pressure (mmHg)	134 [133; 136]	-4.8 [-3.7; -5.8]	<0.0001	-7.1 [-8.3; -6.0]	<0.0001
Diastolic blood pressure (mmHg)	82 [81; 83]	-2.6 [-3.2; -2.0]	<0.0001	-4.2 [-5.0; -3.5]	<0.0001
LDL cholesterol (mg/dL)	131 [127; 136]	-11.1 [-13.4; -9.0]	<0.0001	-18.2 [-21.2; -15.3]	<0.0001
HDL cholesterol (mg/dL)	49.7 [47.0; 52.3]	1.5 [-0.5; 3.5]	0.15	2.9 [0.7; 5.0]	<0.0001
Triglycerides (mg/dL)	185 [174; 196]	-23 [-34; -12]	<0.0001	-39 [-45; -32]	0.009
Fasting plasma insulin (μu/mL)	28.0 [21.8; 34.2]	-3.9 [-6.4; -1.4]	0.002	-5.7 [-8.4; -3.0]	<0.0001
HOMA-IR	8.2 [6.2; 10.2]	-1.6 [-2.3; -0.9]	<0.0001	-2.5 [-3.3; -1.7]	<0.0001
10-year cardiovascular risk (%)	6.5 [5.0; 7.9]	-1.2 [-1.5; -0.8]	<0.0001	-1.8 [-2.4; -1.2]	<0.0001