Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise

Table 1

Effect of diet-induced hyperinsulinemia and exercise on acetyl cholinesterase activity.

	(μmol min^-1/μg protein)	(mM)
Control
HFD	^†††
HFD Ex
HCD	^†††
HCD Ex

Effect of diet-induced hyperinsulinemia and exercise on acetyl cholinesterase activity (km, mM; , μmol min^-1/μg protein) in muscles at 1.5 mM substrate concentration after 30 min incubation of control, high-fat diet (HFD), high-fat diet exercise (HFD Ex), high-carbohydrate diet (HCD), and high-carbohydrate diet exercise (HCD Ex). For determination of substrate kinetics of AChE, acetylthiocholine iodide was used as the substrate over a concentration range of 0.5– 5 Mm. Values are of 4–6 separate experiments ( animals per group). ^†††when compared to the control,andwhen compared to HFD and HCD, respectively.