Atg16L1 as a Novel Biomarker and Autophagy Gene for Diabetic Retinopathy

Table 2

Top ten differentially expressed mRNAs in diabetic retinas compared to undiabetic retinas.

Gene symbol	Description	value	Fold change
Upregulated
Hdc	Histidine decarboxylase	0.0004	1.66
Dnah7b	Dynein, axonemal, heavy chain 7B	0.0009	1.47
Erap1	Endoplasmic reticulum aminopeptidase 1	0.0010	1.47
Alpk2	Alpha-kinase 2	0.0011	1.36
Gsc2	Goosecoid homebox 2	0.0016	1.36
N4bp2l1	NEDD4 binding protein 2-like 1	0.0027	1.27
Skap2	src family-associated phosphoprotein 2	0.0028	1.25
Zscan29	Zinc finger SCAN domains 29	0.0033	1.25
Tmprss7	Transmembrane serine protease 7	0.0039	1.24
Atg16l1	Autophagy-related 16-like 1	0.0043	1.18
Downregulated
Camk1g	Calcium/calmodulin-dependent protein kinase I gamma	0.0002	1.44
Vmn1r121	Vomeronasal 1 receptor 121	0.0003	1.43
Sly	Sycp3 like Y-linked	0.0003	1.40
Serinc5	Serine incorporator 5	0.0004	1.33
Clybl	Citrate lyase beta like	0.0018	1.32
Hist1h1c	Histone cluster 1, H1c	0.0018	1.31
Ubtd2	Ubiquitin domain containing 2	0.0022	1.27
Ttc12	Tetratricopeptide repeat domain 12	0.0030	1.26
Rhobtb1	Rho-related BTB domain containing 1	0.0036	1.26
Duxbl2	Double homeobox B-like 2	0.0037	1.25