Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice

Figure 1

The impact of miR-155 on inflammation, renal morphology, and function in diabetic KK-Ay mice. (a, b) miR-155 expressions serum and kidney tissue as determined using real-time PCR. (c, d) ACR and mAlb levels were used to assess degree of renal function. (e–h) Inflammatory cytokine expressions (MCP-1, TNF-α, IL-1β, and IL-6) in serum was measured using ELISA. (i) The expression levels of nephrin were determined using immunofluorescence. (j) The morphology of the kidney was observed under TEM. ^#Compared with NC group, ; Compared with DN control group, .

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