Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice

Figure 2

Effects of miR-155 on inflammation induced by high glucose-triggered podocyte damage. (a) The expression of miR-155 in podocytes transfected with the miR-155 mimic or inhibitor under high glucose condition determined using real-time PCR. (b–e) Inflammatory cytokines (MCP-1, TNF-α, IL-1β, and IL-6) secretion in podocytes transfected with the miR-155 mimic or inhibitor under high glucose conditions was assessed using ELISA. (f, g) Nephrin expression in podocytes transfected with either a miR-155 mimic or inhibitor was evaluated using real-time PCR and Western blotting analysis. ^#Compared with control group, ; Compared with HG (high glucose) group, .

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