Bradykinin Protects Human Endothelial Progenitor Cells from High-Glucose-Induced Senescence through B2 Receptor-Mediated Activation of the Akt/eNOS Signalling Pathway

<div>The role of B2R and NO in the protective effect of BK against senescence in EPCs. (a) Western blotting for B2R and eNOS in EPCs. (b) Representative photomicrographs of SA-<i>β</i>-gal staining in EPCs. (d) Number of senescent cells after treatment. (c, e) ROS generation was analysed by Mito-Sox. (f-i) Western blotting for P-Ser<sup>473</sup>AKT, T-AKT, and eNOS in EPCs. (j) NO production was detected by NO assay kit. 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Journal of Diabetes Research

fig4

Figure 4

Figure 4: Bradykinin Protects Human Endothelial Progenitor Cells from High-Glucose-Induced Senescence through B2 Receptor-Mediated Activation of the Akt/eNOS Signalling Pathway 

Figure 4 | Bradykinin Protects Human Endothelial Progenitor Cells from High-Glucose-Induced Senescence through B2 Receptor-Mediated Activation of the Akt/eNOS Signalling Pathway 