Characteristics Associated with Early Worsening of Retinopathy in Patients with Type 2 Diabetes Diagnosed with Retinopathy at Their First Visit: A Retrospective Observational Study
Table 1
Summary of the clinical characteristics of patients with simple and preproliferative diabetic retinopathy.
SDR
PPDR
Total
Nonworsening
Worsening
Total
Nonworsening
Worsening
()
()
()
()
()
()
Age (years)
Sex (% male)
80
76
94
79
82
67
Duration of diabetes (years)
, 15>
, 17>
, 11>
, 15>
, 15>
, 13>
Body mass index (kg/m2)
Newly diagnosed diabetes (%)
14
13
18
6
5
11
Previous medication (%) None/non-SU†/SU‡/insulin
33/5/45/17
30/3/46/21
47/12/41/0
36/13/36/15
26/16/42/16
78/0/11/11
New intervention (%) None/non-SU†/SU‡/insulin
64/6/15/15
70/6/11/13
35/12/29/24
62/11/4/23
68/11/0/21
33/11/22/33
Therapy intensification (% yes)
36
30
65
38
32
67
Use of statins (%)
28
30
24
36
37
33
Use of antihypertensive agents (%)
53
59
29
51
45
78
Baseline HbA1c (%)
3 M HbA1c (%)
6 M HbA1c (%)
12 M HbA1c (%)
Δ3 M HbA1c (%)
Δ6 M HbA1c (%)
Δ12 M HbA1c (%)
Baseline systolic blood pressure (mmHg)
Baseline diastolic blood pressure (mmHg)
Baseline triglyceride (mg/dL)
, 239>
, 243>
, 163>
, 173>
, 198>
, 148>
Baseline total cholesterol (mg/dL)
Baseline high density lipoprotein (mg/dL)
Baseline low density lipoprotein (mg/dL)
Baseline non-high-density lipoprotein (mg/dL)
Creatinine (mg/dL)
Uric acid (mg/dL)
Urinary albumin/creatinine ratio (mg/gCre)
, 36>
, 32>
, 50>
, 110>
, 122>
, 99>
Variables are expressed as or st quartile, 3rd quartile>. †Nonsulfonylurea. ‡Sulfonylurea.
