Research Article

A Network Pharmacology-Based Approach for Exploring Key Active Compounds and Pharmacological Mechanisms of Tangshen Formula for Treatment of Diabetic Nephropathy

Table 1

Basic information of 50 candidate active ingredients was collected for the Tangshen Formula (TSF).

No.TCMSP IDMolecule nameMolecular weightOBDL

1MOL000033(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R,5S)-5-propan-2-yloctan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol428.8236.230.78
2MOL000096(-)-Catechin290.2949.680.24
3MOL000098Quercetin302.2546.430.28
4MOL000211Mairin456.7855.380.78
5MOL000239Jaranol314.3150.830.29
6MOL000296Hederagenin414.7936.910.75
7MOL000354Isorhamnetin316.2849.60.31
8MOL000358Beta-sitosterol414.7936.910.75
9MOL000359Sitosterol414.7936.910.75
10MOL0003713,9-di-O-Methylnissolin314.3653.740.48
11MOL0003787-O-Methylisomucronulatol316.3874.690.3
12MOL0003799,10-Dimethoxypterocarpan-3-O-β-D-glucoside462.4936.740.92
13MOL000380(6aR,11aR)-9,10-Dimethoxy-6a,11a-dihydro-6H-benzofurano[3,2-c]chromen-3-ol300.3364.260.42
14MOL000387Bifendate418.3831.10.67
15MOL000392Formononetin268.2869.670.21
16MOL000398Isoflavanone316.33109.990.3
17MOL000417Calycosin284.2847.750.24
18MOL000422Kaempferol286.2541.880.24
19MOL000433FA441.4568.960.71
20MOL0004421,7-Dihydroxy-3,9-dimethoxy pterocarpene314.3139.050.48
21MOL000449Stigmasterol412.7743.830.76
22MOL000471Aloe-emodin270.2583.380.24
23MOL001040(2R)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one272.2742.360.21
24MOL001420ZINC04073977412.77380.76
25MOL001494Mandenol308.56420.19
26MOL001495Ethyl linolenate306.5446.10.2
27MOL00175524-Ethylcholest-4-en-3-one412.7736.080.76
28MOL001771Poriferast-5-en-3beta-ol414.7936.910.75
29MOL001792DFV256.272.5732.76
30MOL002235EUPATIN360.3450.80.41
31MOL002268Rhein284.2347.070.28
32MOL002281Toralactone272.2746.460.24
33MOL002297Daucosterol_qt386.7335.890.7
34MOL002341Hesperetin302.370.310.27
35MOL002879Diop390.6243.590.39
36MOL002883Ethyl oleate (NF)310.5832.40.19
37MOL003137Leucanthoside462.4432.120.78
38MOL004328Naringenin272.2759.290.21
39MOL0051005,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one302.347.740.27
40MOL005344Ginsenoside rh2622.9836.320.56
41MOL0054812,6,10,14,18-Pentamethylicosa-2,6,10,14,18-pentaene342.6733.40.24
42MOL0054863,4-Dehydrolycopen-16-al548.9246.640.49
43MOL005503Cornudentanone378.5639.660.33
44MOL005530Hydroxygenkwanin300.2836.470.27
45MOL005531Telocinobufagin402.5869.990.79
46MOL005552Gemin D634.4968.830.56
47MOL005828Nobiletin402.4361.670.52
48MOL007475Ginsenoside f2785.1436.430.25
49MOL008457Tetrahydroalstonine352.4732.420.81
50MOL013381Marmin332.4338.230.31

Note: OB: oral bioavailability; DL: drug-likeness.