Research Article

A Network Pharmacology-Based Approach for Exploring Key Active Compounds and Pharmacological Mechanisms of Tangshen Formula for Treatment of Diabetic Nephropathy

Table 2

The network topology parameters and active compounds were collected for 27 key TSF-DN cotargets from protein-protein international network.

No.NameDegreeBetweenness centralityCloseness centralityDN target corresponding compounds of TSF

1AKT1580.1130.697Quercetin, kaempferol, naringenin
2TP53500.0930.656Quercetin, aloe-emodin, nobiletin
3IL6540.0770.678Quercetin
4CAT180.0500.521Naringenin, ginsenoside f2
5MAPK8450.0490.639Kaempferol, nobiletin
6VEGFA460.0470.631Quercetin
7JUN450.0370.631Quercetin, kaempferol, beta-sitosterol, rhein, nobiletin
8CASP3320.0370.579Quercetin, kaempferol, beta-sitosterol, aloe-emodin, ginsenoside rh2
9CTNNB1260.0340.544Ginsenoside f2
10MMP9380.0310.596Quercetin
11HMOX1280.0280.569Quercetin, kaempferol
12MAPK1410.0280.611Quercetin, naringenin
13NFKB1220.0260.538Isoflavanone
14EGFR350.0240.589Quercetin
15EGF360.0240.589Quercetin
16IL1B390.0230.593Quercetin, ginsenoside rh2, aloe-emodin
17PTGS2340.0200.586(-)-Catechin, quercetin, jaranol, hederagenin, isorhamnetin, beta-sitosterol, 3,9-di-O-methylnissolin, 7-O-methylisomucronulatol, 9,10-dimethoxypterocarpan-3-O-β-D-glucoside, (6aR,11aR)-9,10-dimethoxy-6a,11a-dihydro-6H-benzofurano[3,2-c]chromen-3-ol, bifendate, formononetin, calycosin, kaempferol, 1,7-dihydroxy-3,9-dimethoxy pterocarpene, stigmasterol, aloe-emodin, (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one, ZINC04073977, mandenol, DFV, EUPATIN, rhein, toralactone, hesperetin, naringenin, 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, ginsenoside rh2, 2,6,10,14,18-pentamethylicosa-2,6,10,14,18-pentaene, cornudentanone, hydroxygenkwanin, aobiletin, tetrahydroalstonine, marmin
18NOS3270.0180.569Quercetin, kaempferol, isorhamnetin, 3,9-di-O-methylnissolin
19CCL2350.0170.586Quercetin
20SERPINE1200.0160.527Quercetin
21MAPK3330.0150.582Kaempferol, nobiletin
22ESR1250.0140.544(-)-Catechin, isorhamnetin, 3,9-di-O-methylnissolin, 7-O-methylisomucronulatol, (6aR,11aR)-9,10-dimethoxy-6a,11a-dihydro-6H-benzofurano[3,2-c]chromen-3-ol, formononetin, calycosin, (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one, DFV, toralactone, naringenin, aobiletin
23CREB1240.0140.541Aobiletin
24IL10330.0120.576Quercetin
25CXCL8350.0120.579Quercetin
26RELA300.0110.556Quercetin, isorhamnetin, kaempferol, naringenin
27PPARG270.0110.559(-)-Catechin, quercetin, isorhamnetin, 7-O-methylisomucronulatol, formononetin, kaempferol, naringenin, aobiletin, ginsenoside f2, tetrahydroalstonine