Exosomes Secreted by Umbilical Cord Blood-Derived Mesenchymal Stem Cell Attenuate Diabetes in Mice

Figure 6

Reduced glucose levels in the MSC and MSC-Exo-treated groups. (a) (i) Representative images of H&E staining () of pancreatic tissue of the STZ+MSC and STZ+MSC-Exo groups compared to the STZ+PBS group. The lower panel shows images of H&E staining with multiple islets (low magnification, ). (ii) Histogram representing number of healthy and damaged cells in islets counted on three different sections (five random fields) in the STZ+PBS, STZ+MSC, and STZ+MSC-Exo groups. (b) Line graph showing blood glucose level in diabetic animals treated with the MSC and MSC-Exo groups compared to the PBS-treated group. (c) Line graph showing body weight in diabetic animals treated with the MSC and MSC-Exo groups compared to the PBS-treated group. Data are shown as the (/group). The significance of differences between mean values was estimated by nonparametric Student’s -test (unpaired, two-tailed) and compared to the PBS-treated group.

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