Islet Transplantation Reverses Podocyte Injury in Diabetic Nephropathy or Induced by High Glucose via Inhibiting RhoA/ROCK/NF-κB Signaling Pathway

Figure 2

Improvement of body weight, blood glucose, renal function, and pathology in mice after islet transplantation. (a) Random blood glucose was measured once a week (islet transplantation model mice established at 18 weeks). (b) The weight of mice was recorded once a week. (c, d) Blood creatinine and urea nitrogen were measured for each group. (e) Urinary albumin-to-creatinine was measured for each group. (f, g) The HE and PAS staining of glomerular structure showed typical pathological changes (The arrow in HE points to the glomerular hypertrophy; the arrow in PAS points to the glomerular basement membrane thickening) ( versus the control group, ^# versus the DN group).

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