Characteristics and Clinical Significance of Intestinal Microbiota in Patients with Chronic Hepatitis B Cirrhosis and Type 2 Diabetes Mellitus

Figure 2

Comparison of intestinal microbiota diversity among HC, LC, and LCDM. (a) The rarefaction curve tends to be flat, indicating that the sequencing depth was sufficient. (b) The rank abundance curve tends to be flat, indicating even species distribution. (c) Chao1 index and (d) ACE index significantly decreased in LCDM. (e) The Venn diagram showed that 892 OTUs were shared between LC and LCDM, and 301 OTUs were unique to LCDM. (f) The β diversity of PCoA analysis based on binary Jaccard distance showed that the samples of intestinal microbiota in the HC group were clustered and were farther away from those in the LC and LCDM groups, while the spatial distance between samples in the LC and LCDM groups was less. HC: healthy controls; LC: HBV-related liver cirrhosis; LCDM: hepatitis B liver cirrhosis and diabetes mellitus.

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