2-O-Methylperlatolic Acid Enhances Insulin-Regulated Blood Glucose-Lowering Effect through Insulin Receptor Signaling Pathway

Figure 4

2-O-Methylperlatolic acid (2-O-M) enhanced the insulin-activated hypoglycemic effect in db/db mice. (a) Blood glucose change within 120 minutes in db/db mice. (b) Serum insulin level at 120 minutes. Serum C-peptide level at 120 minutes. Serum glucagon level at 120 minutes. Expression of key proteins of the insulin signaling pathway in muscle. Data are shown as the ( in each group). ; ; versus control. versus insulin. , 2-O-M versus insulin+2-O-M.

(a)

(b)