A Low Free T3 to Free T4 Ratio Is Associated with Sarcopenia in Euthyroid Patients with Type 2 Diabetes Mellitus

Table 3

Logistic regression analysis of thyroid hormones and the components of sarcopenia.

Independent variable	Model 1		Model 2		Model 3
	OR (95% CI)		OR (95% CI)		OR (95% CI)
Muscle mass
FT3, per 1 pmol/L	0.700 (0.469-1.045)	0.081	0.670 (0.429-1.048)	0.079	0.659 (0.412-1.056)	0.083
FT4, per 1 pmol/L	1.089 (0.995-1.193)	0.066	1.110 (1.004-1.226)	0.041	1.114 (1.009-1.232)	0.036
FT3/FT4, per 0.01 unit	0.953 (0.918-0.988)	0.009	0.944 (0.906-0.983)	0.006	0.943 (0.905-0.981)	0.006
TSH, per 1 μIU/mL	0.823 (0.655-1.035)	0.096	0.902 (0.705-1.156)	0.416	0.903 (0.703-1.162)	0.429
Muscle strength
FT3, per 1 pmol/L	0.384 (0.238-0.620)	<0.001	0.476 (0.284-0.796)	0.005	0.525 (0.305-0.902)	0.020
FT4, per 1 pmol/L	1.056 (0.953-1.171)	0.295	1.074 (0.961-1.201)	0.207	1.077 (0.960-1.207)	0.207
FT3/FT4, per 0.01 unit	0.931 (0.891-0.973)	0.001	0.938 (0.895-0.984)	0.008	0.945 (0.901-0.992)	0.021
TSH, per 1 μIU/mL	0.818 (0.622-1.077)	0.152	0.770 (0.573-1.033)	0.081	0.746 (0.548-1.015)	0.062
Physical performance
FT3, per 1 pmol/L	0.372 (0.241-0.575)	<0.001	0.474 (0.292-0.770)	0.003	0.443 (0.259-0.758)	0.003
FT4, per 1 pmol/L	1.062 (0.970-1.162)	0.193	1.094 (0.989-1.210)	0.081	1.087 (0.980-1.206)	0.115
FT3/FT4, per 0.01 unit	0.929 (0.895-0.965)	<0.001	0.931 (0.892-0.971)	0.001	0.934 (0.894-0.975)	0.002
TSH, per 1 μIU/mL	0.947 (0.759-1.181)	0.628	0.853 (0.660-1.101)	0.222	0.835 (0.639-1.091)	0.186

Notes: model 1, unadjusted; model 2, adjusted for age, gender, smoking habit, drinking habit, duration of DM, hypertension, and HbA1c; model 3, adjusted for age, gender, smoking habit, drinking habit, duration of DM, hypertension, HbA1c, eGFR, TG, HDL-C, and body fat percentage. Abbreviations: FT3: free triiodothyronine; FT4: free thyroxine; TSH: thyroid-stimulating hormone; OR: odds ratio; CI: confidence interval. .