San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway

Figure 1

Therapeutic effects of SHYS on DKD model rats. DKD rats were orally treated with different dosages of SHYS, the therapeutic effects of SHYS on DKD were evaluated through measuring the body weight change, FBG, level of 24 h urine protein, and pathological changes in the kidney. (a) SHYS treatment reduced the body weight loss in DKD model rats. (b) SHYS treatment decreased the FBG level in DKD model rats. (c) SHYS treatment reduced the level of 24 h urine protein in DKD model rats. (d, e) HE staining showed that the pathological changes in the kidney in DKD model rats were improved after SHYS treatment (black arrows indicated the glomerular hyperplasia; blue arrows indicated the renal tubule atrophy; yellow arrows indicated the inflammatory cell infiltration) () (d). SHYS treatment also lowered the HE score of kidney injury in rats with DKD (e). (f)–(i) The Masson (f, g) and Sirius red (h, i) staining showed that SHYS treatment decreased the accumulation of collagen contents in kidney (black arrows indicated the positive expression area) (). Control, model, SHYS low-dose, and SHYS high-dose groups ( per group) ^##: compared with the control group; : compared with the model group; : compared with the model group.

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