Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway

<div>Beta-hydroxybutyrate affects endocytosis of proximal tubule epithelial cells through AKT/DAB2/megalin signaling pathway. (a) DAB2, P-AKT, and T-AKT in indicated concentrations of BOHB. (b) Megalin, DAB2, P-AKT, and T-AKT in indicated concentrations of BOHB with SC79 or not. (c) Megalin, DAB2, P-AKT, and T-AKT in indicated concentrations of BOHB with AKT inhibitor or not. (d) FITC-BSA uptake level in HK2 cells. BOHB, beta-hydroxybutyric acid; NC, normal control; SC79, AKT activator. 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Journal of Diabetes Research

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Figure 4

Figure 4: Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway 