Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway

<div>Effects of DAB2 overexpression on AKT/DAB2/megalin expression. (a) DAB2 level in HK-2 cells transfected with GFP-Vector or GFP-DAB2. (b) FITC-BSA uptake levels in HK-2 cells transfected with GFP-Vector or GFP-DAB2. (c) Megalin, DAB2, and AKT in HK-2 cells transfected with GFP-Vector or GFP-DAB2. BOHB, beta-hydroxybutyric acid; NC, normal control; GFP-DAB2, plasmid encoding DAB2; GFP-Vector, plasmid encoding control. 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Journal of Diabetes Research

fig5

Figure 5

Figure 5: Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway 