Regulation of Glucose Insulinotropic Peptide and Intestinal Glucose Transporters in the Diet-Induced Obese Mouse

Figure 2

Effect of GIP on SGLT1 function in mouse proximal jejunum. SGLT1 function was measured as a function of O-methyl-glucose- (OMG-) induced Isc in animals fed a normal diet (a) and a high-fat diet (b). The 10 mM OMG-induced Isc was measured in the presence and absence of serosal GIP (0.5 μM). Open circles are the initial results before animals are separated into the two diet groups (o). The first month is closed boxes (■). The second month is open triangles (Δ). The fifth month is closed circles (•). The seventh month is open diamonds (∇). The ninth month is closed boxes (■) Results presented represent from 4 tissue pairs from 4 mice. ⁺—compared to normal control; —compared to GIP control.

(a)

(b)