Association of Sirtuin 1 Gene Polymorphisms with the Risk of Coronary Heart Disease in Chinese Han Patients with Type 2 Diabetes Mellitus
Table 3
Additive inheritance model of genotype distribution between CHD and control groups.
SNP
Genotype
CHD (%)
Control (%)
OR (95% CI)
OR’ (95% CI’)
rs16924934
A/A
185 (63.1)
140 (72.2)
1
A/G
106 (36.2)
54 (27.8)
1.485 (1.001–2.204)
0.049
1.473 (0.969–2.239)
0.070
G/G
2 (0.7%)
0
/
/
/
/
rs3818292
A/A
129 (44.5)
94 (48.5)
1
G/G
17 (5.9)
11 (5.7)
A/G
144 (49.7)
89 (45.9)
1.179 (0.810–1.715)
0.389
1.216 (0.817–1.810)
0.334
rs12242965
C/C
178 (59.9)
129 (66.2)
1
T/T
8 (2.7)
7 (3.6)
C/T
111 (37.4)
59 (30.3)
1.363 (0.924–2.011)
0.118
1.328 (0.879–2.005)
0.178
rs3818291
G/G
220 (74.1)
158 (81.0)
1
A/A
2 (0.7)
3 (1.5)
G/A
75 (25.3)
34 (17.4)
1.584 (1.006–2.494)
0.047
1.683 (1.033–2.743)
0.037
rs4746720
T/T
89 (30.0)
54 (27.7)
1
C/C
43 (14.5)
31 (15.9)
T/C
165 (55.6)
110 (56.4)
0.842 (0.475–1.492)
0.555
0.768 (0.417–1.416)
0.398
and values were based on comparisons between the CHD group and the control group analyzed by logistic regression. ,, and values were determined after adjusting for age, sex, smoking status, and HDL-c levels. The number of rs16924934 G/G genotype carriers was too small and thus were not included in the analysis.
