Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

Figure 1

T2DM inhibits hair cycling and reduces skin thickness. (a) Representative photo of hair regrowth on the back of mice. S: significant; A: alteration; N: no change. (b) 40% and 60% of control mice show significant hair regrowth and hair follicle alteration, respectively. 20% and 40% of T2DM mice show significant hair regrowth and hair follicle alteration, respectively. The other 40% of mice have no change. (c) Representative photos of hair follicles. Orange arrows direct the hair follicles. (d) T2DM significantly decreased hair follicle size (control vs. T2DM μm, , ) and skin thickness (control vs. T2DM μm, , ). .

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