Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

Figure 2

T2DM inhibits skin cells proliferation. (a) Representative photos of PCNA in the skin. (b) T2DM decreased the PCNA expression in hair follicles (control vs. T2DM , brown area %, , ) and epidermis (control vs. T2DM , brown dot per 100 μm, , ). (c) Representative photos of K14 and DAPI staining in skin. (d) T2DM reduced the depth of K14 in hair follicles (control vs. T2DM , μm, , ). .

(a)

(b)

(c)

(d)