Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism

Figure 1

RLP has a therapeutic effect on DN mice. After 42 days of treatment, all mice were euthanized. The urine, blood, and kidney samples were collected and analysed. The effects of RLP on the change curves of body weight (a) and FBG (b) in each group were examined. The changes in kidney function, such as 24 h UTP (c), Cr (d), and BUN (e), after RLP treatment were also evaluated. Kidney tissues were subjected to HE staining (f) and PAS staining (g) for pathological analysis. In HE staining, black arrows indicated the thickening of the glomerular basement membrane, yellow arrows indicated the cellular swelling of renal tubular epithelial cells, and red arrows indicated the infiltration of inflammatory cells. In PAS staining, black arrows indicated the glomerulus (100×). Control, model, IRB, L-RLP, M-RLP, and H-RLP ( per group) groups. Data are presented as the . ## as compared to the control group; as compared to the model group; as compared to the model group.

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