Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism

Figure 5

RLP alters tryptophan metabolism-related enzymes in the kidney of DN mice. (a–d) RT-qPCR analysis showed that the decreased mRNA levels of key enzymes involved in tryptophan metabolism in kidney of DN mice, such as Kmo, Kynu, Tph1, and Aanat, were improved by RLP treatment. (e–i) Western blot analysis confirmed the increase of KMO, KYNU, TPH1, and AANAT in the kidney of DN mice after RLP treatment.

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