Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism

Figure 6

RLP ameliorates ferroptosis in the kidney of DN mice. The elevated levels of ROS (a) and 4-HNE (b) in the kidney of DN mice were significantly decreased after RLP treatment, which indicated the accumulation of a large amount of lipid peroxides in kidney were scavenged. (c–f) RLP decreased the levels of transferrin and Steap3 while increased the level of GPX4, suggesting that both iron overload and GPX4 depletion have been alleviated.

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