Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism

Figure 7

RLP alters the PI3K/AKT signalling pathway and apoptosis in the kidney of DN mice. (a–c) RLP treatment increased the phosphorylation levels of PI3K and AKT in the kidney of DN mice. (d–f) Elevated levels of apoptosis-related proteins BAX, BCL-2, cleaved-caspase-9, and cleaved-caspase-3 were decreased after RLP treatment, suggesting the apoptosis was ameliorated.

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