Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism
Table 1
Common differential metabolites in the kidney after crocin treatment.
No.
Formula
RT
Metabolites
VIP
FC
Trend
Pathway
M vs. C
R vs. M
M vs. C
R vs. M
M vs. C
R vs. M
1
C10H9NO2
5.67
174.06
2-(1H-indol-3-yl)acetic acid
1.35
1.07
1.65
0.75
↑#
↓
h
2
C7H7NO3
3.31
154.05
3-Hydroxyanthranilic acid
0.97
1.18
0.26
2.47
↓##
↑
h
3
C11H12N2O3
6.55
221.09
5-Hydroxytryptophan
1.63
1.13
0.63
1.52
↓##
↑
h
4
C4H8N2O3
1.24
131.05
Asparagine
1.17
1.20
0.83
1.36
↓
↑
a
5
C9H14N4O3
1.67
225.10
Carnosine
1.36
1.08
0.31
7.47
↓#
↑
c
6
C6H8O7
6.00
191.02
Citric acid
1.43
1.28
1.10
1.48
↑
↑
a
7
C6H13N3O3
1.31
174.09
Citrulline
1.33
0.82
1.63
0.78
↑#
↓
b
8
C6H14NO8P
1.20
258.04
D-Glucosamine 6-phosphate
1.84
1.51
1.54
0.43
↑
↓
a
9
C4H4O4
1.20
115.00
Fumaric acid
0.62
1.24
1.72
0.61
↑##
↓
a
10
C6H13O9P
1.52
261.04
Glucose 1-phosphate
1.17
0.98
0.49
1.81
↓#
↑
g
11
C4H7NO4
1.21
132.03
L-Aspartic acid
1.12
1.70
1.17
0.55
↑
↓
a
12
C5H10N2O3
1.32
147.08
L-Glutamine
1.18
1.19
0.69
1.51
↓#
↑
a, b
13
C6H9N3O2
1.65
154.06
L-Histidine
1.41
0.38
0.57
1.19
↓#
↑
c
14
C10H12N2O3
8.39
209.09
L-Kynurenine
0.69
1.40
0.15
9.61
↓##
↑
h
15
C11H12N2O2
6.70
205.10
L-Tryptophan
1.52
1.65
0.60
1.69
↓#
↑
h
16
C9H11NO3
1.98
180.07
L-Tyrosine
0.40
1.17
0.61
1.57
↓##
↑
d, e
17
C7H14N2O3
1.53
175.11
N-Acetylornithine
1.24
1.15
2.46
0.48
↑##
↓
b
18
C12H14N2O2
7.25
219.11
N-Acetylserotonin
1.22
1.47
0.58
1.39
↓##
↑
h
19
C9H8O3
1.98
163.04
Phenylpyruvic acid
0.81
1.17
0.58
1.61
↓##
↑
d, e
20
C17H21N4O9P
9.46
455.10
Riboflavin-5-phosphate
1.18
0.96
2.22
0.48
↑#
↓
f
21
C9H10O5
7.81
197.05
Syringic acid
1.28
0.80
1.57
0.80
↑#
↓
g
22
C17H20N4O6
7.92
377.15
Vitamin B2
1.44
1.41
0.39
2.03
↓##
↑
f
C: control group; M: model group; R: RLP group; per group. Name of pathways. a: alanine, aspartate and glutamate metabolism; b: arginine biosynthesis; c: histidine metabolism; d: phenylalanine metabolism; e: phenylalanine, tyrosine, and tryptophan biosynthesis; f: riboflavin metabolism; g: starch and sucrose metabolism; h: tryptophan metabolism. #, compared with the control group; ##, compared with the control group; , compared with the model group; , compared with the model group.
