A Causal Relationship Between Type 1 Diabetes and Risk of Osteoporosis: A Univariable and Multivariable Mendelian Randomization Study

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2"><b>Exposure</b></td><td class="align_center" rowspan="2"><b>Outcome</b></td><td class="align_center" colspan="2"><b>IVW</b></td><td class="align_center" colspan="2"><b>MR-Egger</b></td></tr><tr class="thead"><td class="align_center"><span width=""><b>Cochran’s </b><svg height="10.917pt" id="M27" style="vertical-align:-2.20282pt" version="1.1" viewbox="-0.0498162 -8.71418 9.63826 10.917" width="9.63826pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M749 358C749 544 611 667 432 667C180 667 21 482 21 287C21 118 131 1 297 -15L310 -24C447 -124 532 -151 560 -158S670 -172 720 -160L727 -135C647 -102 630 -94 477 -5L465 2C649 55 749 196 749 358ZM592 362C592 218 513 70 428 36L398 54L298 31C218 57 178 165 178 282C178 436 280 622 417 622C541 622 592 521 592 362Z"></path></g></svg></span></td><td class="align_center"><span style="width: 9.63826ptpx;"><svg height="10.917pt" id="M28" style="vertical-align:-2.20282pt" version="1.1" viewbox="-0.0498162 -8.71418 9.63826 10.917" width="9.63826pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M749 358C749 544 611 667 432 667C180 667 21 482 21 287C21 118 131 1 297 -15L310 -24C447 -124 532 -151 560 -158S670 -172 720 -160L727 -135C647 -102 630 -94 477 -5L465 2C649 55 749 196 749 358ZM592 362C592 218 513 70 428 36L398 54L298 31C218 57 178 165 178 282C178 436 280 622 417 622C541 622 592 521 592 362Z"></path></g></svg><b>-</b><svg height="10.108pt" id="M29" style="vertical-align:-3.23369pt" version="1.1" viewbox="-0.0498162 -6.87431 8.20288 10.108" width="8.20288pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 297C600 402 548 454 439 454C406 454 381 453 344 444L365 522L353 528C314 514 254 479 229 455L218 414C184 403 146 388 113 365L123 331C148 346 175 358 208 367L107 -123C95 -180 77 -195 16 -207L9 -241L298 -229L304 -193L287 -192C232 -189 218 -179 229 -125L254 -3C275 -10 291 -12 312 -12C380 4 464 50 513 103C570 165 600 241 600 297ZM465 297C465 180 383 35 323 35C309 35 281 53 271 68L335 394C346 397 360 400 380 400C422 400 465 382 465 297Z"></path></g></svg><b>value</b></span></td><td class="align_center"><span width=""><b>Cochran’s </b><svg height="10.917pt" id="M30" style="vertical-align:-2.20282pt" version="1.1" viewbox="-0.0498162 -8.71418 9.63826 10.917" width="9.63826pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M749 358C749 544 611 667 432 667C180 667 21 482 21 287C21 118 131 1 297 -15L310 -24C447 -124 532 -151 560 -158S670 -172 720 -160L727 -135C647 -102 630 -94 477 -5L465 2C649 55 749 196 749 358ZM592 362C592 218 513 70 428 36L398 54L298 31C218 57 178 165 178 282C178 436 280 622 417 622C541 622 592 521 592 362Z"></path></g></svg></span></td><td class="align_center"><span style="width: 9.63826ptpx;"><svg height="10.917pt" id="M31" style="vertical-align:-2.20282pt" version="1.1" viewbox="-0.0498162 -8.71418 9.63826 10.917" width="9.63826pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M749 358C749 544 611 667 432 667C180 667 21 482 21 287C21 118 131 1 297 -15L310 -24C447 -124 532 -151 560 -158S670 -172 720 -160L727 -135C647 -102 630 -94 477 -5L465 2C649 55 749 196 749 358ZM592 362C592 218 513 70 428 36L398 54L298 31C218 57 178 165 178 282C178 436 280 622 417 622C541 622 592 521 592 362Z"></path></g></svg><b>-</b><svg height="10.108pt" id="M32" style="vertical-align:-3.23369pt" version="1.1" viewbox="-0.0498162 -6.87431 8.20288 10.108" width="8.20288pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 297C600 402 548 454 439 454C406 454 381 453 344 444L365 522L353 528C314 514 254 479 229 455L218 414C184 403 146 388 113 365L123 331C148 346 175 358 208 367L107 -123C95 -180 77 -195 16 -207L9 -241L298 -229L304 -193L287 -192C232 -189 218 -179 229 -125L254 -3C275 -10 291 -12 312 -12C380 4 464 50 513 103C570 165 600 241 600 297ZM465 297C465 180 383 35 323 35C309 35 281 53 271 68L335 394C346 397 360 400 380 400C422 400 465 382 465 297Z"></path></g></svg><b>value</b></span></td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td class="align_left">T1D</td><td class="align_center">Osteoporosis</td><td class="align_center">31.667</td><td class="align_center">0.245</td><td class="align_center">29.919</td><td class="align_center">0.271</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Journal of Diabetes Research

tab3

Table 3

Table 3: A Causal Relationship Between Type 1 Diabetes and Risk of Osteoporosis: A Univariable and Multivariable Mendelian Randomization Study 