Usefulness of Once-Weekly GLP-1 Receptor Agonist Semaglutide on Glycemic Control in Subjects with Type 2 Diabetes Mellitus: Switching from the Same Class Dulaglutide in a Retrospective Observation Study

Table 4

Univariate analysis evaluating the association between ΔHbA1c (after 6 months-at baseline) and various clinical parameters at baseline. (a) Study 1. (b) Study 2.

(a)

Univariate analysis
	ΔHbA1c
Parameter
Age (years)	0.023	0.927
Duration (years)	-0.064	0.795
HbA1c (%)	-0.688	<0.001
PG (mg/dL)	-0.146	0.551
BMI (kg/m^2)	0.038	0.880
γ-GTP (U/L)	0.247	0.323
ALT (U/L)	0.328	0.171
AST (U/L)	0.391	0.100
TG (mg/dL)	-0.392	0.107
HDL-C (mg/dL)	0.096	0.705
LDL-C (mg/dL)	-0.396	0.093
eGFR (mL/min/1.73m^2)	-0.218	0.370

(b)

Univariate analysis (switching)
	ΔHbA1c
Parameter
Age (years)	0.204	0.503
Duration (years)	0.040	0.897
HbA1c (%)	-0.666	0.013
PG (mg/dL)	-0.237	0.436
BMI (kg/m^2)	0.253	0.404
γ-GTP (U/L)	0.306	0.360
ALT (U/L)	0.199	0.515
AST (U/L)	0.506	0.078
TG (mg/dL)	-0.263	0.409
HDL-C (mg/dL)	0.246	0.442
LDL-C (mg/dL)	-0.281	0.353
eGFR (mL/min/1.73m^2)	-0.237	0.436

Abbreviations: BMI: body mass index; PG: plasma glucose; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; eGFR: estimated glomerular filtration rate.