Green Coffee Bean Extract Potentially Ameliorates Liver Injury due to HFD/STZ-Induced Diabetes in Rats

Table 5

The effect of GCBE on oxidative stress.

Experimental groups	CNTR	HFD/STZ	HFD/STZ + Met (200 mg kg^−1)	HFD/STZ + GCBE (50 mg kg^−1)	HFD/STZ + GCBE (100 mg kg^−1)	GCBE (100 mg kg^−1)
MDA level (nmol/mg protein)	10.1 ± 0.3	17.6 ± 0.4^a	11.5 ± 0.6^b	12.2 ± 0.6^b	12.3 ± 0.6^b	10.8 ± 0.4
NO level (mmol/mg protein)	6.5 ± 0.4	17 ± 0.5^a	10.6 ± 0.2^b	11.8 ± 0.5^b	7.5 ± 0.4^bcd	9 ± 0.5^a
GSH level (mmol/mg protein)	31.1 ± 0.3	15.6 ± 0.8^a	26.61 ± 0.7^b	18.71 ± 1.1	30.1 ± 0.8^bcd	30.2 ± 0.6
SOD activity (U/mg protein)	215.6 ± 1.4	160.2 ± 3^a	181.8 ± 2.7^b	204.8 ± 1.5^b	215.6±2^bcd	227.3 ± 0.8^a
CAT activity (U/mg protein)	96.36 ± 0.8	72.07 ± 1^a	86.04 ± 1.5^b	88.1 ± 2.6^b	93.4 ± 2.7^b	96.6 ± 1^bcd

MDA: malondialdehyde, NO: nitric oxide, GSH: reduced glutathione, SOD: superoxide dismutase, and CAT: catalase. Data are represented as the mean ± SE (n = 7). ^aRepresents the statistical significance relative to that of the CNTR group at  < 0.05. ^bRepresents the statistical significance relative to that of the HDF/STZ group at  < 0.05. ^cRepresents the statistical significance relative to that of the HDF/STZ-Met group at  < 0.05.^.dRepresents the statistical significance relative to that of the HDF/STZ-GCBE (50 mg kg⁻¹) group. ^eRepresents the statistical significance relative to that of a group HDF/STZ-GCBE (100 mg kg⁻¹) group.