Low-Dose Alcohol Improves Lipid Metabolism through Store-Operated Ca²⁺ Channel-Induced PPARγ Expression in Obese Mice

Figure 7

Molecular mechanism diagram illustrating low-dose alcohol consumption improved lipid metabolism through SOC-induced PPARγ expression in obese mice. (1) Low-dose alcohol entered the liver cells. (2) Low-dose alcohol upregulated the expressions of STIM1 and Orai1. (3) Extracellular Ca²⁺ entered cytoplasm through SOCs. (4) The expression of PPARγ was upregulated. (5) PPARγ entered the nucleus and regulated the target genes involved in glucose and lipid metabolism.