Mitigating Effect of Dietary Dioclea reflexa (Hook F) Seed Inclusion in Experimental Colon Carcinogenesis

Table 1

Effect of dietary inclusion with different levels of D. reflexa seeds on oxidative stress, some endogenous antioxidant enzymes, and indices of early carcinogenesis in rats following 10 weeks MNU instillation.

Treatments	Malondialdehyde (nmol/mg protein)	Superoxide dismutase (μ/ml)	Catalase (μmol/min/mg protein)	Glutathione s-transferase (μmol/ml/min)	Neutrophil-lymphocyte ratio	Carcinoembryonic antigen (pg/ml)	Mismatch repair gene (%)
Normal control	100 ± 19^ab	30.9 ± 0.4^a	61.5 ± 3.7^a	0.168 ± 0.031^a	0.17 ± 0.07^a	81.4 ± 20.9^a	73.7 ± 1.0^ab
MNU control	259 ± 38^c	13.6 ± 3.0^c	24.2 ± 9.9^d	0.007 ± 0.004^b	3.29 ± 0.34^d	214.2 ± 20.2^c	44.5 ± 1.0^e
2.5% D. reflexa + MNU	128 ± 45^b	16.0 ± 3.7^c	31.6 ± 3.4^c	0.154 ± 0.043^a	3.15 ± 0.20^d	149.4 ± 20.4^c	54.0 ± 0.9^d
5% D. reflexa + MNU	111 ± 40^b	26.6 ± 3.9^b	41.4 ± 5.6^b	0.142 ± 0.020^a	1.65 ± 0.24^c	124.9 ± 22.9^b	69.4 ± 0.8^c
10% D. reflexa + MNU	109 ± 38^b	27.5 ± 2.2^ab	46.0 ± 9.2^b	0.146 ± 0.028^a	1.08 ± 0.18^b	127.8 ± 16.3^b	77.5 ± 1.2^b
10% D. reflexa only	68 ± 38^a	27.4 ± 4.2^ab	49.7 ± 8.1^b	0.167 ± 0.025^a	0.15 ± 0.02^a	80.8 ± 20.9^a	80.7 ± 1.4^a

Values are means ± SD. Values with different superscripts (a, b, c) down the column are significantly different ().