Hesperidin Induced HePG-2 Cell Apoptosis through ROS-Mediated p53/Bcl-2/Bax and p-mTOR Signaling Pathways

<div>Effects of different concentrations of hesperidin on the growth of HepG-2 and LO2. (a) Cell viability was evaluated after being treated with different concentrations of hesperidin for 24 h by the cell counting kit-8 assay, which was measured at 450 nm using the microplate spectrophotometer (VersaMax). (b) Fluorescence microscope was used to observe morphological changes in HepG-2 cells with different concentrations of hesperidin. The length of the scale plate in the footnote is 75 <i>μ</i>m. Different concentration gradients of hesperidin include 40 <i>μ</i>M, 80 <i>μ</i>M, 160 <i>μ</i>M, 320 <i>μ</i>M, and 640 <i>μ</i>M. 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Journal of Food Biochemistry

fig1

Figure 1

Figure 1: Hesperidin Induced HePG-2 Cell Apoptosis through ROS-Mediated p53/Bcl-2/Bax and p-mTOR Signaling Pathways 