Isochlorogenic Acid C Restrains Erk/JNK/NF-κB Signaling to Alleviate Inflammatory Response and Promote Cell Apoptosis

Figure 8

Effects of ICAC on animal growth and inflammatory swelling of feet. 40 male Wistar rats were randomly divided into 4 groups according to body weight: control (vehicle), CIA (collagen-induced arthritis), CIA-ICAC-L (50 mg/kg), and CIA-ICAC-H (100 mg/kg). After successful replication of the CIA animal model, intervention was continued for 5 weeks, body weight was measured and recorded once a week, arthritis score was performed once a week, and volume after collagen-induced swelling was measured once a week. (a) The growth curve of rats (n = 10); (b) the severity of arthritis by the arthritis score; (c) the left hind foot (n = 10); (d) the right hind foot (^## vs. control group; vs. CIA group, n = 10).

(a)

(b)

(c)

(d)