Isochlorogenic Acid C Restrains Erk/JNK/NF-κB Signaling to Alleviate Inflammatory Response and Promote Cell Apoptosis

Figure 9

Effects of ICAC on animal bone tissue and synovium. (a) After collagen induction, paw swelling was evident in the model group compared with the control group, but significantly decreased after ICAC treatment; (b) micro-CT was used to take photos of the left hind foot to construct three-dimensional images. Images showed significant bone destruction in all rats after collagen stimulation compared with control mice; (c) HE stained the synovium of the left joint; (d) ICAC treatment was able to significantly reduce the paw bone destruction. Bone surface (BS) to bone volume (BV) ratio in the left hind foot (n = 10); (e) the synovium pathological score of the left joint after HE staining. The number of cell proliferation and the degree of tissue fibrosis were assessed under an ordinary microscope, and the assessment of pathological features was 0 (normal), 1 (mild), 2 (moderate), and 3 (severe) (^## vs. control group; vs. CIA group, n = 10).

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