Efficacy for Bone Deterioration in Mice with Osteoporosis and Pharmaceutical Properties of a Novel Compound Calcium Carbonate Granule

Figure 2

CCCG improved femoral and tibia deterioration, body weight, and organ index in osteoporosis (OP) mice. (a) The selected OP model was constructed using RA and subjected to test blood calcium, blood phosphorus, and body weight 21 d after gavage. (b, c) Images of 2D reconstruction obtained by micro-CT and the microstructure parameters of BV/TV, Tb.Th, and Tb.Sp was compared between the control and model groups (n = 5). (d) Effects of treatment with CCCG at different doses on body weight for 36 days. (e) Images of the femur of the right leg of mice in different experimental groups. A: control group; B: model group; C: CCCG-low; D: CCCG-medium; E: CCCG-high; F: CCD. (f) Length and diameter of femurs, weight of the femur and tibia. (g) Organ index of the kidney, liver, and spleen. Control: normal mice; model: RA-induced OP model mice; CCCG-L: low-dose CCCG-treated OP model mice; CCCG-L: middle-dose CCCG-treated OP model mice; CCCG-H: high-dose CCCG-treated OP model mice; CCD: CCD-treated OP mice. , and ; n = 6 or 7 per group.

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