Antrodia cinnamomea Extract Attenuates Cisplatin-Induced Muscle Atrophy, Apoptosis, and Cell Growth Suppression

Figure 2

EEAC impaired C/G-suppressed myotube formation of C2C12 cells. C2C12 cells treated with control vehicle (CTR), EEAC (10 μg/ml), C/G (1 μM cisplatin and 1 μM gemcitabine), and EEAC combined with C/G (EEAC + C/G) were differentiated into elongated myotubes. (a) Representative images of C2C12 differentiated elongated myotubes. (b) Representative histological images of MHC-positive and multinucleated myotubes. (c) Fusion index was indicated as number of nuclei in MHC-positive myotubes divided by total number of nuclei. ; .

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