Network Pharmacology-Based Approach to Explore the Total Flavonoids of Phellinus igniarius against Hyperuricemia via Regulating the Nrf2/HO-1-ROS-ER Signaling Pathway

Figure 8

Impact of TFPI on the expression of ER and apoptosis pathway-related proteins in HK-2 cells. (a) Western blot and corresponding histograms of Bip, PERK, ATF4, and chop protein expression relative to β-actin. (b) Western blot and corresponding histograms of BAX, Bcl-2, and cleaved caspase 3 protein expression relative to β-actin. Data are means ± SD (n = 3).  < 0.01, compared with the control; ^# < 0.05, ^## < 0.01, compared with the model.

(a)

(b)