Houttuynia cordata Polysaccharide Ameliorates Chronic Inflammation-Induced Intestinal Impairment by Zonula Occludens-1 in Rats

Figure 5

Effects of HCP on SCFAs and pH value in colonic contents of chronic inflammatory rats. (a–f) The effect of HCP on the content of SCFAs, which includes: (a) acetic acid; (b) propionic acid; (c) isobutyric acid; (d) butyric acid; (e) isovaleric acid; (f) valeric acid. (g) Effect of HCP on pH value of intestinal contents. Long-term LPS stimulation significantly diminished SCFAs secretion in colonic contents and interfered with intestinal acid-base homeostasis of chronic inflammatory rats in the LPS group. HCP suppressed inflammation by regulating anti-inflammatory compounds SCFAs, as evidenced by the enhancement of SCFAs content and the lower pH value in HCP treatment groups when compared to the LPS group. ^##indicates extremely significant difference compared with control group (); indicates significant difference compared with LPS group (), indicates extremely significant difference compared with LPS group ().

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