Ursolic Acid Inhibits the Growth of Gastric Cancer by Targeting KLF4/YAP1

Figure 3

KLF4 inhibited the growth of GC cells through downregulation of CTGF. (a) Changes of CTGF, P21, and P27 mRNA levels in BGC-823 cells after overexpression of KLF4. (b) The inhibition of cell proliferation in BGC-823 cells after downregulation of CTGF. (c) Flow cytometric analysis of the cell cycle of BGC-823 cells after downregulation of CTGF. (d) G2/M and S-phase analysis of the cell cycle of BGC-823 cells after downregulation of CTGF. (e) Changes of P21 and P27 mRNA levels in BGC-823 cells after downregulation of CTGF. (f) Western blot analyses of p-AKT and CTGF expression levels after downregulation of CTGF.

(a)

(b)

(c)

(d)

(e)

(f)