Astragaloside IV Suppresses the Effects of Hepatocellular Carcinoma Cells on Proliferation, Angiogenesis, and Invasion in Human Umbilical Vein Endothelial Cells by Controlling Exosomes by Inhibiting Rab27a

Figure 4

AS-IV inhibits the effects of Hep3B and SK-Hep1 cells on the proliferation, invasion, and angiogenesis of HUVECs. (a, b) Proliferation, (c, e) invasion, and (d, f) angiogenesis of HUVECs cocultured with Hep3B or SK-Hep1 cells pretreated with 20 and 50 m AS-IV. (g, h) Concentration of Hep3B or SK-Hep1 cells-derived exosomes was measured by NTA. Scale bar: 100 m. All data are expressed as the mean ± SD, n = 3.  < 0.05,  < 0.01,  < 0.001 vs. Hep3B, SK-Hep1, or control.

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