Total Flavone Content of Cydonia oblonga Miller Inhibits Proliferation and Migration of Renal Carcinoma Cells by Inhibiting the S1PR2/FAK Pathway

Figure 1

TFCOM inhibited the proliferation of 786-O and Renca cells. (a–c) H1975, A549, and MCF-7 cells were treated with 10, 20, 40, 80, and 160 μg/ml of TFCOM for 48 h; (d) MDCK cells were exposed to the indicated doses of TFCOM for 48 h. 786-O and Renca cells were treated with 20, 40, 80, 160, 320, and 640 μg/ml of TFCOM for 48 h (e, f); IC50 of TFCOM on 786-O and Renca cells in 48 h (g, h). Cell viability was analyzed by CCK-8 assay, and the surviving cells were determined and presented as a percentage of the nontreated cells. Data are presented as mean ± standard deviation (SD) in three independent experiments. , , and , as compared with the nontreated control.

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