Total Flavone Content of Cydonia oblonga Miller Inhibits Proliferation and Migration of Renal Carcinoma Cells by Inhibiting the S1PR2/FAK Pathway

Figure 4

(a) Prediction and screening results of targets of active ingredients in renal cell carcinoma. The node size indicates the importance of the node in the network. (b) Analyses of the drug-ingredient-gene symbol-disease network. RCC and TFCOM share common target Venny diagram. (c) Protein-protein interaction network and the network of interactions between active components and corresponding targets. The color scale indicates the p value, and the dot size indicates the gene count in each term. (d) Changes in the levels of p53 proteins after being normalized to the levels of GAPDH. Data are shown as mean ± SD of three independent experiments. , as compared with the nontreated control group. (e) GO analysis of the biological process (BP), mitotic G1 DNA damage checkpoint, G1 DNA damage checkpoint, and mitotic G1/S transition checkpoint were screened out. (f) GO analysis in the cellular component category; cyclin-dependent protein kinase holoenzyme complex, serine/threonine kinase complex, and protein kinase complex were obtained. (g) GO analysis in the molecular function category. (h) KEGG analysis, CXCR chemokine receptor binding, and sulfur compound binding were screened out.

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