Research Article
Total Flavone Content of Cydonia oblonga Miller Inhibits Proliferation and Migration of Renal Carcinoma Cells by Inhibiting the S1PR2/FAK Pathway
Figure 5
TFCOM inhibited migration of RCC by regulating S1PR2/FAK signaling pathway. (a) Protein level of migration is checked on 786-O cells treated with TFCOM extract 48 h. S1PR2/p-FAK is consistently reduced after being treated by TFCOM. (b) Changes in the levels of S1PR2/FAK proteins after being normalized to the levels of GAPDH are presented. (c) Protein level of migration is checked on Renca cells treated with TFCOM 48 h. S1PR2/p-FAK was consistently reduced after being treated with TFCOM. (d) Changes in the levels of S1PR2/FAK proteins after being normalized to the levels of GAPDH are presented. Data are shown as mean ± SD of three independent experiments. , , as compared with the nontreated control group.
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