Total Flavone Content of <i>Cydonia oblonga</i> Miller Inhibits Proliferation and Migration of Renal Carcinoma Cells by Inhibiting the S1PR2/FAK Pathway

<div>Schematic of proliferation, apoptosis, and migration induced by TFCOM via Wnt/<i>β</i>-catenin, S1PR2/FAK, and PI3K/AKT/mTOR signaling pathway. Our data suggest that TFCOM extract inhibits the migration of RCC by regulating S1PR2/FAK signaling pathway; TFCOM inhibits proliferation and migration by regulating PI3K/AKT/mTOR and Wnt/<i>β</i>-catenin signaling pathway; TFCOM induces apoptosis of RCC by regulating p53, Bax, Bcl-2, caspase 3, and PARP.</div>

Journal of Food Biochemistry

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Figure 8

Figure 8: Total Flavone Content of <i>Cydonia oblonga</i> Miller Inhibits Proliferation and Migration of Renal Carcinoma Cells by Inhibiting the S1PR2/FAK Pathway 

Figure 8 | Total Flavone Content of Cydonia oblonga Miller Inhibits Proliferation and Migration of Renal Carcinoma Cells by Inhibiting the S1PR2/FAK Pathway 