Allicin-Mediated Cell Cycle Regulation Reverses Taxol Resistance in NSCLC: Molecular Insights and Therapeutic Potentia

Figure 1

Effects of allicin on proliferation and migration of A549/Taxol cells. (a) The inhibition rate of allicin at different concentrations on A549/Taxol cells was detected by MTT assay at 24, 48, and 72 hours of treatment; (b) the inhibition rates of different concentrations of Taxol combined with allicin (IC₁₀) on A549/Taxol cells was detected by MTT assay at 24, 48, and 72 h; (c) representative Images (A) and statistical analysis (B) of colony formation in A549/Taxol cells with different concentrations of allicin combined with Taxol (300 nM); (d) wound healing assay was performed in A549/Taxol cells with different concentrations of allicin combined with Taxol (300 nM) at for 0, 24, and 48 h, respectively; representative images (A) and statistical analysis (B, C). (e) Hoechst 33342 staining results for 48 h in A549/Taxol cells. Strong blue fluorescence indicated apoptotic cells, scale bar = 100 µm. The data were expressed as mean ± SD, compared with the negative control group,  < 0.05,  < 0.01,  < 0.001.