Nuciferine Promotes Longevity and Fitness in Caenorhabditis elegans through the Regulation of the Insulin/IGF-1 Signaling Pathway

Figure 3

Effects of nuciferine on the stress resistance and antioxidant abilities in the wild-type worms. (a) Survival curves of the N2 nematodes under oxidative stress. The log-rank (Kaplan–Meier) test by SPSS was employed for statistical analysis ( and ). (b) Survival curves of the N2 nematodes under thermal stress. Survival rates were analyzed by the log-rank (Kaplan–Meier) test using SPSS and detailed data are summarized in supporting information Table S2. (c) The SOD enzyme activities were quantified. (d) The CAT enzyme activities were quantified. (e) The GSH contents were quantified. Data were represented as mean ± SD, n = 3. Statistical significance was obtained at , , , and by ANOVA with Tukey’s multiple comparisons test using GraphPad Prism 9.0.

(a)

(b)

(c)

(d)

(e)