Nuciferine Promotes Longevity and Fitness in Caenorhabditis elegans through the Regulation of the Insulin/IGF-1 Signaling Pathway

Table 1

Effect of nuciferine on the lifespan of wild-type (N2) worms at 20°C.

Group	Mean lifespan (days ± SEM)	Percentage change	Number of worms	P value
Control	17.85 ± 0.38^a	—	158	—
Nuciferine 50 μM	19.29 ± 0.43^b	8.06%	164	0.0002
Nuciferine 100 μM	20.50 ± 0.57^c	14.86%	152	<0.0001
Nuciferine 200 μM	19.97 ± 0.54^bc	11.89%	161	<0.0001

Different letters (a, b, and c) indicated a significant difference between the two groups. values were determined by the log-rank test using the Kaplan–Meier survival analysis (). Mean lifespan values were calculated by the log-rank test and presented as mean ± SEM by SPSS.