Immune-Enhancing Activity of Vitis coignetiae Extract via Increasing Cytokine and Natural Killer Cell Activity in Splenocytes and Cyclophosphamide-Induced Immunosuppressed Rats

Figure 9

Effect of Vitis coignetiae extract (VCE) on immunity-associated spleen damage in cyclophosphamide (Cy)-induced immunosuppressed rats. Wistar rats were treated with saline, Cy (5 mg/kg/d), and oral VCE (0, 50, 250, and 500 mg/kg/d) once daily for four weeks, after which spleen damage was analyzed histologically. Representative images of the sectioned spleens of (a) normal rats (saline), (b) control rats (Cy only), (c-e) VCE-treated rats (treated with Cy and (c) 50 mg/kg, (d) 250 mg/kg, or (e) 500 mg/kg of VCE), and (f) positive control rats (treated with Cy and 1,000 mg/kg of HemoHIM). Scale bar = 100 μm. CV: central vein; LN: lymph nodule; MZ: marginal zone; and RP: red pulp.

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