The Antimelanogenic Activity of the Extract of Heukharang Lettuce (Lactuca sativa L.) Leaf

Figure 6

Schematic diagram of α-MSH-induced melanogenesis. HHE downregulates the CREB/MITF signaling pathway, leading to subsequent reduction in the expression of melanogenic proteins (TYR, TRP-1, and TRP-2) and melanin synthesis.