Effect of Cholesterol to Vitamin D3 and Span 60 to Tween 60 Ratios on the Characteristics of Niosomes: Variable Optimization Using Response Surface Methodology (RSM)
Table 4
Estimated coefficients of multiple determinations (R2) for encapsulation efficiency using coded values.
Source
Sum of squares
df
Mean square
F-value
value
Model
13727.9
5
2745.58
858.94
<0.0001
Significant
A-A
89.02
1
89.02
27.85
0.0033
B-B
5.62
1
5.62
1.76
0.242
AB
1888.57
1
1888.57
590.83
<0.0001
A2
22.35
1
22.35
6.99
0.0457
B2
10998.03
1
10998
3440.67
<0.0001
Residual
15.98
5
3.2
Lack of fit
15.42
3
5.14
18.26
0.0524
Not significant
Pure error
0.5629
2
0.2814
Corrected total
13743.89
10
R 2: 0.9988; adjusted R2: 0.9977; predicted R2: 0.9919.
